LSD "is used to treat conditions like depression, post-traumatic stress disorder and addiction," notes Science Daily. And now a microbiology student "has found a long sought-after fungus that produces effects similar to the semisynthetic drug..." Morning glory plants live in symbiosis with fungi that produce the same ergot alkaloids the Swiss chemist Albert Hofmann modified when he invented LSD in the late 1930s. Hofmann hypothesized that a fungus in morning glories produced alkaloids similar to those in LSD, but the species remained a mystery...

The researchers dubbed the fungus "Periglandula clandestina" for its ability to have eluded investigators for decades.

MIT comp-sci professor Ryan Williams suspected that a small amount of memory "would be as helpful as a lot of time in all conceivable computations..." writes Quanta magazine.

"In February, he finally posted his proof online, to widespread acclaim..." Every algorithm takes some time to run, and requires some space to store data while it's running. Until now, the only known algorithms for accomplishing certain tasks required an amount of space roughly proportional to their runtime, and researchers had long assumed there's no way to do better. Williams' proof established a mathematical procedure for transforming any algorithm — no matter what it does — into a form that uses much less space.

What's more, this result — a statement about what you can compute given a certain amount of space — also implies a second result, about what you cannot compute in a certain amount of time. This second result isn't surprising in itself: Researchers expected it to be true, but they had no idea how to prove it. Williams' solution, based on his sweeping first result, feels almost cartoonishly excessive, akin to proving a suspected murderer guilty by establishing an ironclad alibi for everyone else on the planet. It could also offer a new way to attack one of the oldest open problems in computer science.

"It's a pretty stunning result, and a massive advance," said Paul Beame, a computer scientist at the University of Washington.
Thanks to long-time Slashdot reader mspohr for sharing the article.

Physicists at Loughborough University have created what they believe is the world's smallest violin, measuring just 35 microns long and 13 microns wide -- smaller than the width of a human hair, which typically ranges from 17 to 180 microns in diameter. The microscopic instrument, created using the university's new nanolithography system, serves as a demonstration of precision manufacturing capabilities that researchers will apply to studies of computing efficiency and energy harvesting methods.

The team used a NanoFrazor machine employing thermal scanning probe lithography, where a heated needle-like tip etches highly precise patterns at the nanoscale onto a chip coated with gel-like resist material. While the individual violin takes roughly three hours to produce, the research team spent several months refining their techniques to achieve the final result, which exists as a microscopic image rather than a playable instrument.

Japan-based Ispace confirmed its Resilience lander likely crashed during its second failed attempt at a lunar landing, after a sensor malfunction prevented proper deceleration. Despite the setback, the company remains committed to future missions, with funding secured for a third attempt using a new lander, Apex 1.0, scheduled for 2027. "Until then, Ispace has its work cut out for it," reports CNN. "[Ispace CEO and founder Takeshi Hakamada] said during the news briefing he will need to work to regain the trust of investors, and the company will need to deeply investigate what went wrong on the Resilience mission to ensure similar issues don't plague Apex 1.0."

The company has ambitious "plans to eventually build a city on the lunar surface that would house a thousand people and welcome thousands more for tourist visits," notes ABC News. "If ispace is going to establish a colony on the moon, it will need to identify an ample supply of ice or water, which it will convert into fuel for a future lunar fueling station. The ability to produce fuel on the moon will enable the company to transport people back and forth between the Earth and the moon."

alternative_right shares a report from Phys.Org: Using conventional propulsion and low-energy trajectories, it takes six to nine months for crewed spacecraft to reach Mars. These durations complicate mission design and technology requirements and raise health and safety concerns since crews will be exposed to extended periods in microgravity and heightened exposure to cosmic radiation. Traditionally, mission designers have recommended nuclear-electric or nuclear-thermal propulsion (NEP/NTP), which could shorten trips to just 3 months. In a recent study, a UCSB physics researcher identified two trajectories that could reduce transits to Mars using the Starship to between 90 and 104 days.

The study was authored by Jack Kingdon, a graduate student researcher in the Physics Department at the University of California, Santa Barbara (UCSB). He is also a member of the UCSB Weld Lab, an experimental ultracold atomic physics group that uses quantum degenerate gases to explore quantum mechanical phenomena. [...] As outlined on its website, conference presentations, and user manual, the SpaceX mission architecture consists of six Starships traveling to Mars. Four of these spacecraft will haul 400 metric tons (440 U.S. tons) of cargo while two will transport 200 passengers. Based on the Block 2 design, which has a 1,500 metric ton (1,650 U.S. ton) propellant capacity, the crewed Starships will require 15 tankers to fully refuel in low Earth orbit (LEO). The cargo ships would require only four, since they would be sent on longer low-energy trajectories. Once the flotilla arrives at Mars, the Starships will refuel using propellant created in situ using local carbon dioxide and water ice. When the return window approaches, one of the crew ships and 3-4 cargo ships will refuel and then launch into a low Mars orbit (LMO). The cargo ships will then transfer the majority of their propellant to the crew ship and return to the surface of Mars. The crew ship would then depart for Earth, and the process could be repeated for the other crew ship.

Kingdon calculated multiple trajectories using a Lambert Solver, which produces the shortest elliptical arc in two-body problem equations (aka Lambert's problem). The first would depart Earth on April 30th, 2033, taking advantage of the 26-month periodic alignment between Earth and Mars. The transit would last 90 days, with the crew returning to Earth after another 90-day transit by July 2nd, 2035. The second would depart Earth on July 15th, 2035, and return to Earth after a 104-day transit on December 5th, 2037. As Kingdon explained, the former trajectory is the most likely to succeed: "The optimal trajectory is the 2033 trajectory -- it has the lowest fuel requirements for the fastest transit time. A note that may not be obvious to the layreader is that Starship can very easily reach Mars in ~3 months -- in fact, it can in any launch window, over a fairly wide range of trajectories. However, Starship may impact the Martian atmosphere too fast (although we do not know, and likely SpaceX don't either actually how fast Starship can hit the Martian atmosphere and survive). The trajectories discussed are ones that I am confident Starship will survive." The paper describing the work has been published in the journal Scientific Reports.

Researchers in Japan have developed a plastic that dissolves in seawater within hours, offering up a potential solution for a modern-day scourge polluting oceans and harming wildlife. From a report: While scientists have long experimented with biodegradable plastics, researchers from the RIKEN Center for Emergent Matter Science and the University of Tokyo say their new material breaks down much more quickly and leaves no residual trace.

At a lab in Wako city near Tokyo, the team demonstrated a small piece of plastic vanishing in a container of salt water after it was stirred up for about an hour. While the team has not yet detailed any plans for commercialisation, project lead Takuzo Aida said their research has attracted significant interest, including from those in the packaging sector.

Anne Wojcicki has asked a U.S. judge to reopen the auction for 23andMe, claiming she has backing from a $400+ billion Fortune 500 company. Reuters reports: South San Francisco, California-based 23andMe filed for bankruptcy in March, seeking to sell its business at auction after a decline in consumer demand and a 2023 data breach that exposed sensitive genetic and personal information of millions of customers. Last month, Regeneron Pharmaceuticals agreed to buy the firm for $256 million, topping a $146 million bid from Wojcicki and TTAM Research Institute, which was founded by Wojcicki and describes itself as a California non-profit public benefit corporation.

In a filing dated May 31, Wojcicki claimed that 23andMe's debtors had attempted to tilt the sales process away from TTAM and in favor of Regeneron. TTAM and Wojcicki said in the filing that 23andMe's financial and legal advisers unfairly capped their maximum bid at $250 million due to misplaced concerns about TTAM's "financial wherewithal." The plaintiffs said the auction was prematurely concluded before they had the opportunity to submit a bid that would have exceeded $280 million.

The company's debtors said the auction results came after an extensive and careful consideration by a four-member special committee of independent directors, according to the filing. According to another filing, 23andMe is seeking court approval to let Wojcicki and Regeneron submit final proposals by June 12. 23andMe is also seeking a $10 million breakup fee for Regeneron if Wojcicki's bid is ultimately accepted.

The James Webb Space Telescope has discovered the most distant galaxy ever observed, named MoM z14. NASA estimates it existed just 280 million years after the Big Bang. Space.com reports: Prior to the discovery of MoM z14, the galaxy holding the title of earliest and distant was JADES-GS-z14-0, which existed just 300 million years after the Big Bang, or around 13.5 billion years ago. This previous record galaxy has a redshift of z =14.32, while MoM z14 has a redshift of z = 14.44. There is a wider context to the observation of MoM z14 than the fact that it has broken the record for earliest known galaxy by 20 million years, though, as [explained team member and Yale University professor of Astronomy and Physics Pieter van Dokkum].

The researchers were able to determine that MoM z14 is around 50 times smaller than the Milky Way. The team also measured emission lines from the galaxy, indicating the presence of elements like nitrogen and carbon. "The emission lines are unusual; it indicates that the galaxy is very young, with a rapidly increasing rate of forming new stars," van Dokkum said. "There are also indications that there is not much neutral hydrogen gas surrounding the galaxy, which would be surprising: the very early universe is expected to be filled with neutral hydrogen. "That needs even better spectra and more galaxies, to investigate more fully."

The presence of carbon and nitrogen in MoM z14 indicates that there are earlier galaxies to be discovered than this 13.52 billion-year-old example. That is because the very earliest galaxies in the universe and their stars were filled with the simplest elements in the cosmos, hydrogen and helium. Later galaxies would be populated by these heavier elements, which astronomers somewhat confusingly call "metal," as their stars forged them and then dispersed them in supernova explosions. The research has been published on arXiv.

An anonymous reader quotes a report from IEEE Spectrum: In a development straight out of science fiction, Australian startup Cortical Labs has released what it calls the world's first code-deployable biological computer. The CL1, which debuted in March, fuses human brain cells on a silicon chip to process information via sub-millisecond electrical feedback loops. Designed as a tool for neuroscience and biotech research, the CL1 offers a new way to study how brain cells process and react to stimuli. Unlike conventional silicon-based systems, the hybrid platform uses live human neurons capable of adapting, learning, and responding to external inputs in real time. "On one view, [the CL1] could be regarded as the first commercially available biomimetic computer, the ultimate in neuromorphic computing that uses real neurons," says theoretical neuroscientist Karl Friston of University College London. "However, the real gift of this technology is not to computer science. Rather, it's an enabling technology that allows scientists to perform experiments on a little synthetic brain."

The first 115 units will begin shipping this summer at $35,000 each, or $20,000 when purchased in 30-unit server racks. Cortical Labs also offers a cloud-based "wetware-as-a-service" at $300 weekly per unit, unlocking remote access to its in-house cell cultures. Each CL1 contains 800,000 lab-grown human neurons, reprogrammed from the skin or blood samples of real adult donors. The cells remain viable for up to six months, fed by a life-support system that supplies nutrients, controls temperature, filters waste, and maintains fluid balance. Meanwhile, the neurons are firing and interpreting signals, adapting from each interaction.

The CL1's compact energy and hardware footprint could make it attractive for extended experiments. A rack of CL1 units consumes 850-1,000 watts, notably lower than the tens of kilowatts required by a data center setup running AI workloads. "Brain cells generate small electrical pulses to communicate to a broader network," says Cortical Labs Chief Scientific Officer Brett Kagan. "We can do something similar by inputting small electrical pulses representing bits of information, and then reading their responses. The CL1 does this in real time using simple code abstracted through multiple interacting layers of firmware and hardware. Sub-millisecond loops read information, act on it, and write new information into the cell culture." The company sees CL1 as foundational for testing neuropsychiatric treatments, leveraging living cells to explore genetic and functional differences. "It allows people to study the effects of stimulation, drugs and synthetic lesions on how neuronal circuits learn and respond in a closed-loop setup, when the neuronal network is in reciprocal exchange with some simulated world," says theoretical neuroscientist Karl Friston of University College London. "In short, experimentalists now have at hand a little 'brain in a vat,' something philosophers have been dreaming about for decades."

Live-animal markets across Southeast Asia continue operating as natural laboratories for deadly pathogens despite warnings from public health experts about their role in disease transmission, according to new research published in Nature.

Scientists studying markets like Jakarta's Jatinegara found that coronavirus detection rates in trafficked animals increase dramatically along supply chains, with rats sold at Vietnamese markets testing positive at rates ten times higher than those caught in fields. Pangolins confiscated in Vietnam showed a seven-fold increase in coronavirus infections compared to animals seized earlier in the smuggling process.

The research comes as political headwinds have severely reduced funding for pandemic preparedness, with the Trump administration terminating a $125-million disease monitoring program and cutting all USAID functions. Scientists report growing reluctance from government officials to authorize publication of pathogen discoveries, fearing stigma and trade restrictions, while wildlife traders increasingly avoid participating in studies that could reveal new health risks.

President Trump's 2026 budget proposes over $1 billion for Mars exploration through a new Commercial Mars Payload Services Program, while simultaneously slashing NASA's overall budget by 25%. Phys.Org reports: Under the proposal, NASA would award contracts to companies developing spacesuits, communications systems and a human-rated landing vehicle to foster exploration of the Red Planet. Trump's proposed $18.8 billion NASA budget would cut the agency's funding by about 25% from the year before, with big hits to its science portfolio. The fleshed-out request on Friday builds upon a condensed budget proposal released earlier this month.

"We must continue to be responsible stewards of taxpayer dollars," NASA Acting Administrator Janet Petro wrote in a letter included in the request. "That means making strategic decisions -- including scaling back or discontinuing ineffective efforts." The new Mars scheme is modeled after NASA's Commercial Lunar Payload Services program that has benefited Intuitive Machines LLC, Firefly Aerospace Inc. and Astrobotic Technology Inc., though it has achieved mixed results. According to the budget, the contract to land on Mars would build upon existing lander contracts. America's Next NASA Administrator Will Not Be Former SpaceX Astronaut Jared Isaacman

New simulations suggest that the long-assumed collision between the Milky Way and Andromeda galaxies is not guaranteed, with the odds now estimated at just over 50% within the next 10 billion years. Factoring in other massive galaxies like M33 and the Large Magellanic Cloud revealed that their gravitational influence significantly alters the likelihood of a merger. ScienceAlert reports: The Milky Way and Andromeda are not, however, alone in this little corner of the cosmos. They belong to a small group of galaxies within a radius of about 5 million light-years from the Milky Way known as the Local Group. The Milky Way and Andromeda are the largest members, but there are quite a few other objects hanging out that need to be taken into consideration when modeling the future. [Astrophysicist Till Sawala of the University of Helsinki] and his colleagues took the latest data from the Hubble and Gaia space telescopes, and the most recent mass estimates for the four most massive objects in the Local Group -- the Milky Way, Andromeda, the Triangulum galaxy (M33), and the Large Magellanic Cloud (LMC). Then, they set about running simulations of the next 10 billion years, adding and removing galaxies to see how that changed the results.

Their results showed that the presence of M33 and LMC dramatically altered the probability of a collision between the Milky Way and Andromeda. When it is just the two large spiral galaxies, the merger occurred in slightly less than half the simulation runs. The addition of M33 increased the merger probability to two in three. Taking M33 back out and adding LMC had the opposite effect, decreasing the probability to one in three. When all four galaxies were present, the probability of a merger between the Milky Way and Andromeda within 10 billion years is slightly more than 50 percent. "We find that there are basically two types of outcomes," Sawala said. "The Milky Way and Andromeda will either come close enough on their first encounter (first 'pericenter') that dynamical friction between the two dark matter haloes will drag the orbit to an eventual merger, which very likely happens before 10 billion years, or they do not come close enough, in which case dynamical friction is not effective, and they can still orbit for a very long time thereafter."

"The main result of our work is that there is still significant uncertainty about the future evolution -- and eventual fate -- of our galaxy," Sawala added. "Of course, as a working astrophysicist, the best results are those that motivate future studies, and I think our paper provides motivation both for more comprehensive models and for more precise observations."

The research has been published in Nature Astronomy.

An anonymous reader quotes a report from The Guardian: People born more recently are less likely to have dementia at any given age than earlier generations, research suggests, with the trend more pronounced in women. According to the World Health Organization, in 2021 there were 57 million people worldwide living with dementia, with women disproportionately affected. However, while the risk of dementia increases with age, experts have long stressed it is not not an inevitability of getting older. "Younger generations are less likely to develop dementia at the same age as their parents or grandparents, and that's a hopeful sign," said Dr Sabrina Lenzen, a co-author of the study from the University of Queensland's Centre for the Business and Economics of Health. But she added: "The overall burden of dementia will still grow as populations age, and significant inequalities remain -- especially by gender, education and geography."

Writing in the journal Jama Network Open, researchers in Australia report how they analyzed data from 62,437 people aged 70 and over, collected from three long-running surveys covering the US, England and parts of Europe. The team used an algorithm that took into account participants' responses to a host of different metrics, from the difficulties they had with everyday activities to their scores on cognitive tests, to determine whether they were likely to have dementia. They then split the participants into eight different cohorts, representing different generations. Participants were also split into six age groups. As expected, the researchers found the prevalence of dementia increased by age among all birth cohorts, and in each of the three regions: UK, US and Europe. However, at a given age, people in more recent generations were less likely to have dementia compared with those in earlier generations.

"For example, in the US, among people aged 81 to 85, 25.1% of those born between 1890-1913 had dementia, compared to 15.5% of those born between 1939-1943," said Lenzen, adding similar trends were seen in Europe and England, although less pronounced in the latter. The team said the trend was more pronounced in women, especially in Europe and England, noting that one reason may be increased access to education for women in the mid-20th century. However, taking into account changes in GDP, a metric that reflects broader economic shifts, did not substantially alter the findings. A number of factors could be contributing to the decline. "This is likely due to interventions such as compulsory education, smoking bans, and improvements in medical treatments for conditions such as heart disease, diabetes, and hearing loss, which are associated with dementia risk," said Prof Tara Spires-Jones, the director of the Centre for Discovery Brain Sciences at the University of Edinburgh.

Automated web-scraping bots seeking training data for AI models are flooding scientific databases and academic journals with traffic volumes that render many sites unusable. The online image repository DiscoverLife, which contains nearly 3 million species photographs, started receiving millions of daily hits in February this year that slowed the site to the point that it no longer loaded, Nature reported Monday.

The surge has intensified since the release of DeepSeek, a Chinese large language model that demonstrated effective AI could be built with fewer computational resources than previously thought. This revelation triggered what industry observers describe as an "explosion of bots seeking to scrape the data needed to train this type of model." The Confederation of Open Access Repositories reported that more than 90% of 66 surveyed members experienced AI bot scraping, with roughly two-thirds suffering service disruptions. Medical journal publisher BMJ has seen bot traffic surpass legitimate user activity, overloading servers and interrupting customer services.

Adam Riess won a Nobel Prize in Physics for helping discover that the universe's acceleration is expanding, remembers The Atlantic. But then theorists "proposed the existence of dark energy: a faint, repulsive force that pervades all of empty space... the final piece to what has since come to be called the 'standard model of cosmology.'"

Riess thinks instead we should just replace the standard model: When I visited Riess, back in January, he mentioned he was looking forward to a data release from the Dark Energy Spectroscopic Instrument, a new observatory on Kitt Peak, in Arizona's portion of the Sonoran Desert. DESI has 5,000 robotically controlled optic fibers. Every 20 minutes, each of them locks onto a different galaxy in the deep sky. This process is scheduled to continue for a total of five years, until millions of galaxies have been observed, enough to map cosmic expansion across time... DESI's first release, last year, gave some preliminary hints that dark energy was stronger in the early universe, and that its power then began to fade ever so slightly. On March 19, the team followed up with the larger set of data that Riess was awaiting. It was based on three years of observations, and the signal that it gave was stronger: Dark energy appeared to lose its kick several billion years ago.

This finding is not settled science, not even close. But if it holds up, a "wholesale revision" of the standard model would be required [says Colin Hill, a cosmologist at Columbia University. "The textbooks that I use in my class would need to be rewritten." And not only the textbooks — the idea that our universe will end in heat death has escaped the dull, technical world of academic textbooks. It has become one of our dominant secular eschatologies, and perhaps the best-known end-times story for the cosmos. And yet it could be badly wrong. If dark energy weakens all the way to zero, the universe may, at some point, stop expanding. It could come to rest in some static configuration of galaxies. Life, especially intelligent life, could go on for a much longer time than previously expected.

If dark energy continues to fade, as the DESI results suggest is happening, it may indeed go all the way to zero, and then turn negative. Instead of repelling galaxies, a negative dark energy would bring them together into a hot, dense singularity, much like the one that existed during the Big Bang. This could perhaps be part of some larger eternal cycle of creation and re-creation. Or maybe not. The point is that the deep future of the universe is wide open...
"Many new observations will come, not just from DESI, but also from the new Vera Rubin Observatory in the Atacama Desert, and other new telescopes in space. On data-release days for years to come, the standard model's champions and detractors will be feverishly refreshing their inboxes..." And Riess tells The Atlantic he's disappointed when complacent theorists just tell him "Yeah, that's a really hard problem."

He adds, "Sometimes, I feel like I am providing clues and killing time while we wait for the next Einstein to come along."